The PC coterie is based on mutual membership in a local band. Maybe they hooked up after their embrace, more likely their band is important to local politics (or their music has mystical significance) and their sires took an interest in them on that account. Perks include groupies to feed on, music and dance based devotions/disciplines, and the quest for the Ultimate Groove. On the other hand, they have to contend with that werewolf band that's beating them to all the best gigs, "creative differences" within the band, guys trying to steal their artifact instruments, and The Man.
Lawyers, Guns & Money
Three words: Vampire lobbying firm. Designed to both advance vampire political interests directly, and rack up favors from members of the business community who have heard of their almost unnatural ability to seal the deal. The PCs start out at the bottom, kept busy mostly scaring punks away from their K Street property and shaking down "the competition." As they earn a little more trust from upper management, they start getting tapped to "entertain" clients. And there are always the jobs they do on the side, either for groups they belong to or for their own self interest.
Elysium is the best local beaches, and the Prince rules the waves. In addition to all the usual things vampires have to do to maintain rank, the PCs have to show their stuff on the water. Alternatively, they're a bunch of surf punks, with more than just good surfing to defend in their "territory."
World of Darkness 2020
Cyberpunk + Vampires = Awesome. This one would take a little rejiggering of the rules, some adjustments to the skill set and a new equipment list at the very least, but it could work. The moods, particularly, mesh pretty well, the whole "our world, but darker, controlled by forces beyond our control" thing being a feature of both genres.
City of the Damned
Set in a real fantasy world -- none of this "our world, but darker" nonsense. Most of the world is overrun by monsters and cultists and generally unpleasant critters. The vampire rulers of the city defend it from those menaces, but at a terrible price. The players are new to the "city defense force," drafted to replace a few veterans who died under very mysterious circumstances. Should they, as they've been instructed, ignore that mystery and get on with their monster hunting duties? The attendant life of luxury they live during their off hours argues most persuasively in favor of looking the other way, but then there's the question of where exactly all those monsters are coming from, and just how benevolent the elders in charge of the city really are.
Vampires in Spaaaaace!
They are probably also pirates. Vampire space pirates. Yeah, that's the ticket. Pretty much just steal the system generation and space travel rules from Traveller, then let the PCs figure out how to feed while stuck in warp. On the bright side, there's no sun in deep space. No, I don't have any excuse for this.