Scary Go Round
I've said it before, and I'll say it again: This is a good comic. Very funny. Lots of weirdness. (Not as much mad science as it used to have, sadly.)
You're probably already reading this, but if you aren't (and you like this blog) you probably should be. (If you hate this blog, I'm not going to be much help.) It has a lot of jokes that I don't understand, because they involve advanced math, but the jokes that I do understand are unbelievably funny.
Order of the Stick
Again, you're probably already reading this. If you aren't, you should start soon, or there is no hope for you or the human race. I'm serious. This is a really, really good comic. Lots of Dungeons and Dragons jokes but, hey, another reason for people to play D&D.
This one's actually over, but they're re-releasing it, with commentary, one strip a day, so it's going to be around for another six years. However, you should read the whole strip plain first, because otherwise, you're quickly going to learn a lot of major plot points. Plot points the comic builds up to over years of strips. Needless to say, this is a really awesome comic. Mad scientists are always awesome.
Looking For Group
Another one I've mentioned before. It's only gotten more awesome.
This one's maybe not quite as good as the others, but it's good and getting better. (And, seriously, "not as good as the Order of the Stick" almost doesn't count as information.) It's about superheroes. It references the evil overlord list. In a word, awesome.